Product Information
The CelliGen 510 is a compact sterilizable-in-place cell culture system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.
Gas flow
› Various combinations of one, two, three or four TMFCs:
0.06 – 3 SLPM
0.3 – 15 SLPM
0.6 – 32 SLPM
1 – 64 SLPM
› Air Wash System with TMFC (0 – 15 or 0 – 32 SLPM)
› Overlay with TMFC (0 – 15 or 0 – 32 SLPM)
› Overlay (valve only)
Exhaust line
› Exhaust condenser
› Manual or automatic pressure control
Impellers
› Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired.
› Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing. Provided as standard with the CelliGen 510 bioreactors.
› Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing
› Spinfilter – For suspension or microcarrier cultures where a dip tube inside the filter withdraws cell media as harvest or waste
› Cell-Lift – Specially designed to provide uniform circulation for both suspension and microcarrier cultures. Can be used with optional decanting columns for perfusion cultures
› Packed-bed – For secreted products from anchorage-dependent and suspension cells, this impeller immobilizes cells in a bed of Fibra-Cel® Disks to provide extremely high cell densities
Sensors
› Single or redundant pH/DO
› Redox
› Foam/level
Addition and sampling
› Resterilizable sampling valve
› Resterilizable addition valves (4 max)
› Resterilizable addition/harvest valve with dip tube (2 max)
› 1.5 in sanitary fitting 7-port septum
› Addition vessels (glass/stainless steel)
› Decanters
› Sterile sampling assembly
Validation
› Basic Package
› Basic Plus Package
› Enhanced Package
Utility regulator & pre-filter kits
› Process air pre-filter/regulator kit
› Instrument air pre-filter/regulator kit
› Water pre-filter/regulator kit
› Process steam regulator kit
› Utility steam pre-filter/regulator kit
› Utility connection kit
Additional options
› Sprayballs for clean-in-place of vessel
› External variable-speed pumps
› External scales
› Spare parts kits
› Preventative maintenance kits
› Mobile table
› System passivation
› Glycol/chiller heat exchanger
